TCR V Alpha24-J Alpha18 anticorps

N° du produit ABIN7540469

Cet anticorps Souris Monoclonal détecte spécifiquement dans FACS, ICC et IHC (fro). Il présente une réactivité envers Humain et Non-Human Primate.

Aperçu rapide pour TCR V Alpha24-J Alpha18 anticorps (ABIN7540469)

Antigène: TCR V Alpha24-J Alpha18

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 6B11

Détail du produit

Fonction: Anti-Hu TCR Valpha24-Jalpha18 Purified

Specificité: The mouse monoclonal antibody 6B11 recognizes an extracellular epitope within V alpha 24 J alpha 18 TCR, which is expressed by invariant NK T cells (iNKT).

Purification: Purified by protein-A affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détail du antigène

Antigène: TCR V Alpha24-J Alpha18

Autre désignation: TCR Valpha24-Jalpha18

Sujet: TCR alpha V24-J18 chain is a marker of invariant NK T cells (iNKT). This chain pairs mostly with TCR beta V11 chain, and together they interact with glycolipide-loaded CD1d. This interaction results in iNKT activation and cytokine production (IFN gamma, IL-4, IL-13), which takes important part in immune regulation and host response to pathogens and cancer(support of both Th1 and Th2 way), although iNKT cells represent less than 1 % of total peripheral T cells.